益處維持細胞健康促進正常的細胞循環活動促進不健康細胞的細胞凋亡（程序性細胞死亡）促進核因子活化B細胞κ輕鏈增強子（NF-κB － 蛋白質）與環氧合酵素（COX-2 － 酵素）的正常活性促進SIRT-1基因（參與卡路里限制、脂肪代謝、粒線體功能）的正常活性促進心血管健康（促進正常的血小板功能、有助維持正常的血管舒張、為低密度脂蛋白粒子提供抗氧化防護）卓越的抗氧化和高ORAC值益處為什麼選擇Isotonix Resveratrol白藜蘆醇配方粉末？細胞和心血管健康欠佳正在成為全世界範圍的流行病

不健康的飲食習慣（包括加工、高卡路里及高脂食品）、污染、吸煙和缺乏運動，均會導致細胞和心臟健康欠佳

科學家發現了「法國悖論」，即雖然法國人飲酒、吸煙、食用高脂食品，但他們的心血管和細胞患病比率卻相當低

科學家將此現象歸因於法國人大量飲用紅酒，更歸因於紅酒中的一種萃取成分 — 白藜蘆醇

臨床研究證實，白藜蘆醇支援心血管和正常細胞健康

由於紅酒經過高度加工，其實際白藜蘆醇含量較低

每天飲用三瓶以上紅酒才可能體驗到白藜蘆醇萃取物的功效

另外，紅酒中的白藜蘆醇成分不固定，因酒的品種、地區和加工工藝而異

白藜蘆醇萃取物Resveravine®的濃縮配方可保證人體獲取白藜蘆醇的全部營養功效，而無須面對飲用三瓶紅酒的副作用

*Isotonix Resveratrol白藜蘆醇配方粉末是以等滲透溶液傳輸的營養補充品，含有三種專利成分：Resveravine（含20% 白藜蘆醇萃取）,BioVin® Advanced（含5%白藜蘆醇萃取）和可促進正常細胞健康的VitaBlue® (野生藍莓萃取)

Isotonix Resveratrol白藜蘆醇配方粉末可維持細胞健康, 促進正常細胞週期活動, 促進不健康細胞的凋亡（計畫性細胞死亡）, 支援SIRT-1基因正常活動, 並透過促進健康血小板功能、促進血管舒張和為低密度脂蛋白粒子提供抗氧化保護達到增進心血管健康的目的

Resveravine結合了反式白藜蘆醇（20%純度）和藤莖中萃取的葡萄素，兩者協效運作可增強白藜蘆醇萃取的功效

反式白藜蘆醇是用於釀造紅酒的葡萄和果汁中主要的同分異構物，Resveravine中反式白藜蘆醇的濃度比葡萄皮製成的其他產品高100至300倍

奧勒岡州立大學鮑林研究所(Linus Pauling Institute)的研究表明，反式白藜蘆醇的生物可利用性可能高於白藜蘆醇的其他同分異構物

比起單純的白藜蘆醇萃取，Resveravine可更高效地對抗自由基及氧化壓力，更有力地促進正常細胞活動，並為低密度脂蛋白粒子提供更多抗氧化保護

*針對多個物種的研究顯示，降低卡路里與延長壽命有關聯

SIRT-1基因可啟動哺乳動物體內限制卡路里的關鍵機制，促進脂肪代謝

有證據顯示，白藜蘆醇可能是一種卡路里限制模擬物, 這種複合物並不限制卡路里的攝入，而是通過作用於受卡路里限制影響的代謝和壓力反應路徑，模擬卡路里限制的效果，從而有助延長壽命

通過促進健康的SIRT-1基因活動，白藜蘆醇促進健康的粒線體功能，支援能量消耗，從而達到促進體重健康的效果

*等滲透表示「相等的壓力」，和人體血液、血漿和眼淚具有相似的化學成分

人體內所有體液都有特定的濃度，稱為滲透壓

人體各種體液普遍的滲透壓，稱為等滲透壓，能讓身體組織維持日常運作

營養素必須要處於等滲透狀態，才能有效地被身體吸收並運用於新陳代謝

Isotonix等滲透營養補充品透過等滲透溶液傳遞，使身體輕鬆吸收最多的營養

等滲透溶液使營養素能直接到達小腸，並快速被血液所吸收

Isotonix產品能減少養分流失，促進營養素的高效吸收，達到最佳保健效果

成分Key Ingredients Found In Isotonix® Resveratrol:Resveravine® (20% resveratrol extract): 10 mgResveratrol is a natural antioxidant found in red wine. Resveravine is a natural extract from Vitis vinifera standardized to contain 20% oligostilbenes. Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products made from grape skin. It provides antioxidant protection of low-density lipoprotein (LDL) particles, promotes normal platelet activity, vasorelaxation and blood flow, all which support cardiovascular health. It has been shown to promote apoptosis (programmed cell death) in unhealthy cells. Another proposed mechanism of action involves the study of the SIRT-1 gene (also known at the longevity gene). Sirtuins, known as Silent Information Regulators (SIRs), are deacetylase enzymes identified in all living creatures. Sirtuin proteins are known to play an important role in keeping regions of chromosomes turned off. Sirtuin controls the enzyme that converts acetate, a source of calories, into acetyl-CoA, a key component of cellular respiration. In humans, there are seven different sirtuins, SIRT-1 to SIRT-7. SIRT-1 has been studied by scientist for its potential effect on human cell lifespan.*Resveratrol promotes normal activity of SIRT-1. Studies have shown that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization. The most recent study (Nature 2006) demonstrated that obese mice fed red wine extract (resveratrol) were in better health and lived longer than obese mice that were not fed the red wine extract. The resveratrol group were more able to maintain heart health compared to mice that were not fed resveratrol. SIRT-1 activation also supports healthy mitochondrial function and supports energy expenditure. Resveratrol has also been shown to have phytoestrogen activity and may support optimal estradiol activity. Other studies have documented neuroprotective benefits associated with resveratrol supplementation.*A comparison test was made to evaluate the activating effect on human SIRT-1 of Resveravine and pure trans -resveratrol. Only the trans-resveratrol form of the molecule promotes normal activation of the mammalian SIRT-1 gene in vitro test. Resveravine was more than eight times more likely to promote SIRT-1 activity than pure trans -resveratrol, showing that Resveravine is more efficient than resveratrol in promoting the normal activity of SIRT-1. Therefore, while the specific mechanisms of SIRT-1 and resveratrol are still unclear, the studies show that SIRT-1 is essential in lifespan extension and health improvement, and resveratrol promotes SIRT-1 activity.*Studies in numerous species have demonstrated that reduction of calories 30 to 50 percent below ad libitium levels of a nutritious diet can promote a longer lifespan, improve overall health, promote normal stress resistance and decelerate functional decline. Studies showed that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization in adipocytes by repressing PPAR (test conducted on mice). Because healthy fat levels have been show to promote a longer murine lifespan, it is suggested that calorie restriction could be connected to SIRT-1 and life extension in mammals.As an alternative strategy, new research has focused on the development of calorie restriction mimetics, compounds that mimic the effect of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake. Resveratrol has been suggested as a potential calorie restriction mimetic.Supplementing mice with resveratrol significantly increases their aerobic capacity. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting healthy weight. In vivo test conducted on mice on a high-calorie diet, resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and promotes their overall health.BioVin® Advanced (French Red Wine Extract with 5% resveratrol): 200 mgRed wine extract containing oligomeric proanthocyanins (OPCs), known to be extremely effective in supporting cardiovascular health by supporting normal blood circulation, strengthening blood vessels and promoting normal platelet activity. BioVin Advanced provides OPCs and additional Resveratrol. The red wine grape contains two main constituents shown to be of significant antioxidant value: red wine polyphenols (flavonoids) and trans-resveratrol (mentioned above). Oligomeric proanthocyanins are flavonoid complexes that act as super potent antioxidants in the human body. BioVin Advanced combines the antioxidant properties of OPCs with trans- resveratrol to promote phase 2 metabolizing enzymes, which are involved in the detoxification of the body’s cells, promoting apoptosis (programmed cell death) in unhealthy cells, promoting healthy cholesterol levels and general free-radical scavenging properties.*VitaBlue® Wild Blueberry Extract (12.5% anthocyanins): 50 mgBlueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanin gives blueberries (and other fruits) their rich blue and red coloring, and is a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as the promotion of healthy cells and apoptosis (programmed cell death). Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. VitaBlue Wild Blueberry Extract supports the body’s COX-2 inhibitors and provides powerful antioxidants in much higher quantities than fresh blueberries, and show to be effective in promoting cardiovascular health, contributing to normal cell cycle traverse, and maintaining overall cellular health.*常見問答常見問題：白藜蘆醇含有酒的萃取物，此產品是否不含酒精成份？是

白藜蘆醇不含酒精成份，而此產品也是不含酒精的

食用愛尚它 ® 紅酒酒粕、藍莓、葡萄萃取精華粉末（含白藜蘆醇） 有哪些禁忌嗎？有

婦女在懷孕或哺乳期間，請勿使用本品

如果您患有疾病或正服用處方藥物，使用本品前，請先諮詢醫護人員意見

如果我是飲酒者，我可否仍食用由紅酒成份製成的 愛尚它 ® 紅酒酒粕、藍莓、葡萄萃取精華粉末（含白藜蘆醇） ？可以

愛尚它 ® 紅酒酒粕、藍莓、葡萄萃取精華粉末（含白藜蘆醇） 並不含有酒精，白藜蘆醇是從製造紅酒的葡萄皮及葡萄提取出來的萃取物

此產品是否適合素食者？是

愛尚它 ® 紅酒酒粕、藍莓、葡萄萃取精華粉末（含白藜蘆醇） 是素食產品

此產品是否男女均適合食用？是

然而，擁有雌激素過敏癌症（乳癌、卵巢癌及子宮癌）病史的女性不應食用此產品

懷孕及哺乳期間之女士不應食用此產品

哪些人應食用此產品？所有希望維持整體健康的成年人，都應按建議食用量每日食用愛尚它 ® 紅酒酒粕、藍莓、葡萄萃取精華粉末（含白藜蘆醇）

科學Scientific Studies Which Support Isotonix® Resveratrol:· Aggarwal B et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research. 24(5A):2783-840, 2004.· Bauer, J. H., et al. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A. 101:12980-12985, 2004.· Baur J et al. Resveratrol improves health and survival of mice on a high-calorie diet.Nature. 444(7117):337-42, 2006.· Belguendouz, L., et al. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochemical Pharmacology. 53(9):1347-1355, 1997.· Bhat K et al. Biological effects of resveratrol. Antioxidants and Redox Signaling. 3(6):1041-64, 2001. Review.· Borra M et al. Mechanism of human SIRT1 activation by resveratrol. Journal of Biological Chemistry. 280(17):17187-95, 2005.· Chen Y. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery.136(1):57-66, 2004.· Dario et al. Resveratrol prolongs life span and retards the onset of age-related markers in a short-lived vertebrae. Current Biology, 2006.· Ding, X. Z., et al. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas. 25(4):71-76, 2002.· Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutation Research. 523-524:145-150, 2003.· Donnelly L et al. Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol, 2004 .· Faria A et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. Journal of Agricultural and Food Chemistry. 53(17):6896-902, 2005.· Frémont L. Biological effects of resveratrol. Life Sciences 66:663-673, 2000.· Fremont, L., et al. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sciences. 64(26):2511-2521, 1999.· Garvin S et al. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Letters. 231(1):113-22, 2006.· Goh S et al. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxidant Redox Signal. 9(1):101-13, 2007.· Hao H et al. Mechanisms of cardiovascular protection by resveratrol. Journal of Medicinal Food. 7(3):290-298, 2004.· Heynekamp J et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. Journal of Medicinal Chemistry. 49(24):7182-9, 2006.· Holmes-McNary M and Baldwin A Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Research. 60:3477-3483, 2000.· Hou D et al. Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins. Journal of Biomedicine and Biotechnology. 2004: (5):321-325, 2004.· Hou D. Potential mechanisms of cancer chemoprevention by anthocyanins. Current Molecular Medicine. 3(2):149-159, 2003.· Howitz, K. T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425(6954):191-6, 2003.· Hung L et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular Research. 47:549-555, 2000.· Hung L et al. Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radicals in Biology and Medicine. 36(6):774-81, 2004.· Hwang J et al. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Annals NY Academy of Sciences . 1095:441-8,2007.· Ignatowicz E and Baer W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Polish Journal of Pharmacology. 53(6):557-69, 2001.· Jang M et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218-220, 1997.· Jang M et al. Cancer chemopreventive activity of resveratrol. Drugs in Experimental Clinical Research. 25:65-77, 1999.· Kaeberlein M et al. Substrate-specific activation of sirtuins by resveratrol. Journal of Biological Chemistry. 280(17):17038-45, 2005.· Kim, Y. A., et al. Antiproliferative effect of resveratrol in human prostate carcinoma cells. Journal of Medicinal Food. 6(4):273-280, 2003.· Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? European Journal of Endocrinology. 138(6):619-620, 1998.· Kundu, J. K., et al. Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets. Biofactors. 21(1-4):33-39, 2004.· Lagouge M et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT-1 and PGC-1alpha. Cell. 127(6):1109-22, 2006.· Lepoivre M et al. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Letters. 421:277-279, 1998.· Lin J et al. Chemoprevention of cancer and cardiovascular disease by resveratrol.Proceedings of the National Science Council Republic of China . 23(3):99-106, 1999. Review.· Manna S et al. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis: potential role of oxygen intermediates and lipid peroxidation. Journal of Immunology. 164(12):6509-6516, 2000.· Manna S et al. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis: potential role of oxygen intermediates and lipid peroxidation. Journal of Immunology. 164(12):6509-6516, 2000.· Martín A et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochemical Pharmacology. 67(7):1399-410, 2004.· Martín A et al. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. British Journal of Pharmacology. 147(8):873-85, 2006.· Martinez J and Moreno J. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochemical Pharmacology. 59:865-870, 2000.· Mgbonyebi O. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. International Journal of Oncology. 12(4):865-869, 1998.· Nielsen M et al. Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochemical and Biophysical Research Communications. 275:804-809, 2000.· Olas B and Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thrombosis Research. 106(2):143-8, 2002.· Olas B and Wachowicz B. Resveratrol reduces oxidative stress induced by platinum compounds in blood platelets. General Physiology and Biophysics. 23(3):315-26, 2004.· Olas B et al. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thrombosis Research. 107(3-4):141-5, 2002.· Olas B et al. Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cellular and Molecular Biology Letters. 9(4A):577-87, 2004.· Pace-Asciak C et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 235:207-219, 1995.· Pace-Asciak C et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 235:207-219, 1995.· Picard F et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429(6993):771-776, 2004.· Porcu M et al. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends in Pharmacological Sciences 26, 2005.· Pozo-Guisado, E., et al. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. International Journal of Cancer 115(1):74-84, 2005.· Provinciali M et al. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer. 115(1):36-45, 2005.· Sato M et al. Journal of Cardiovascular Pharmacology. 35(2):263-268, 2000.· Schneider Y et al. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Letters. 158(1):85-91, 2000.· Sinclair D et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006.· Sovak M. Grape extract, resveratrol, and its analogs: a review. Journal of Medicinal Food. 4(2):93-105, 2001.· Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. Journal of Biological Chemistry. 273:21875-21882, 1998.· Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Annal NY Academy Sciences. 889:214-223, 2000.· Szende B et al. Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Experimental and Molecular Medicine. 32(2):88-92, 2000.· Tsai S et al. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kappaB in macrophages by resveratrol. British Journal of Pharmacology 126:673-680, 1999.· Wang Z et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. International Journal of Molecular Medicine. 9(1):77-9, 2002.· Yi W et al. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. Journal of Agricultural and Food Chemistry 53(18):7320-9, 2005.· Zou J et al. Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med. 11(3):317-20, 2003.· Zou J et al. Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells. International Journal of Oncology. 15:647-651, 1999.